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KMID : 1134820120410050621
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Journal of the Korean Society of Food Science and Nutrition
2012 Volume.41 No. 5 p.621 ~ p.629
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Effect of Soybeans, Chungkukjang, and Doenjang on Blood Glucose and Serum Lipid Profile in Streptozotocin-induced Diabetic Rats
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Kim Ah-Ra
Lee Jae-Joon
Cha Seon-Sook
Chang Hae-Choon
Lee Myong-Ryeol
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Abstract
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This study investigated the effect of soybeans, chungkukjang, and doenjang on blood glucose and serum lipid profile in streptozotocin (STZ)-induced diabetic rats. Male Sprague-Dawley rats weighing 205 g were divided into non-diabetic and diabetic groups. The diabetic groups were further subdivided into four experimental groups: a normal group (N), a diabetic control group (STZ-C), a diabetic group fed autoclaved soybean powder (STZ-S), a diabetic group fed chungkukjang powder (STZ-CKJ) and a diabetic group fed deonjang powder (STZ-DJ). Food and water intakes were higher in the diabetic groups than in the N group. The body weight gain and food efficiency ratios were higher in the STZ-S, STZ-CKJ, and STZ-DJ groups than in the STZ-C group, but created no significant changes between the diabetic groups on food intake and body weight gain. The whole blood level at 4 weeks of the STZ-CKJ group was significantly lower than the STZ-C group. Serum glucose levels of the STZ-S, STZ-CKJ, and STZ-DJ groups were significantly lower than the STZ-C group, but there was no significant change in serum insulin levels. The AST and ALP activities in serum were markedly higher in the STZ-C group, but these decreases in relation to diabetes increased in the STZ-S, STZ-CKJ, and STZ-DJ groups. The level of serum triglycerides was lower in the STZ-CKJ and STZ-DJ groups than in the STZ-C group, whereas level of serum HDL-cholesterol was higher in the STZ-CKJ and STZ-DJ groups. Levels of total serum and LDL-cholesterol were higher in the diabetic groups compared with the N group, but significantly decreased in the STZ-S, STZ-CKJ, and STZ-DJ groups compared to the STZ-C group. These results indicate that dietary supplements of soybean, chungkukjang and doenjang may improve blood glucose and lipid metabolism and help prevent or attenuate the progression of diabetes in STZ-induced diabetic rats.
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KEYWORD
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soybean, chungkukjang, doenjang, diabete, blood glucose
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